Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena.

Like protein enzymes, RNA enzymes (ribozymes) provide specific binding sites for their substrates. We now show that equilibrium dissociation constants for complexes between the Tetrahymena ribozyme and its RNA substrates and products can be directly measured by electrophoresis in polyacrylamide gels...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Pyle, A M, McSwiggen, J A, Cech, T R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54920/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2236030/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.21.8187
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