Use of binding energy by an RNA enzyme for catalysis by positioning and substrate destabilization.
A fundamental catalytic principle for protein enzymes in the use of binding interactions away from the site of chemical transformation for catalysis. We have compared the binding and reactivity of a series of oligonucleotide substrates and products of the Tetrahymena ribozyme, which catalyzes a site...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1995
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42022/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7731962/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.9.3668 |
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