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Use of binding energy by an RNA enzyme for catalysis by positioning and substrate destabilization.

A fundamental catalytic principle for protein enzymes in the use of binding interactions away from the site of chemical transformation for catalysis. We have compared the binding and reactivity of a series of oligonucleotide substrates and products of the Tetrahymena ribozyme, which catalyzes a site...

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Bibliografske podrobnosti
Main Authors: Narlikar, G J, Gopalakrishnan, V, McConnell, T S, Usman, N, Herschlag, D
Format: Artigo
Jezik:Inglês
Izdano: 1995
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC42022/
https://ncbi.nlm.nih.gov/pubmed/7731962
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