Implications of ribozyme kinetics for targeting the cleavage of specific RNA molecules in vivo: more isn't always better.
Kinetic and thermodynamic factors that determine specificity of RNA cleavage by ribozymes are illustrated with examples from recent work with a ribozyme derived from the group I intron of Tetrahymena thermophila pre-rRNA. The conclusions also apply to other ribozymes, to antisense oligonucleotide ex...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autor principal: | |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1991
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52205/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1871108/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.16.6921 |
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