Ribozyme-mediated reversal of the multidrug-resistant phenotype.
This study examined the effects of suppressing c-fos oncogene expression on multidrug resistance (MDR). A2780S human ovarian carcinoma cells with resistance to actinomycin D were isolated and the resultant A2780AD cells exhibited the MDR phenotype. A hammerhead ribozyme designed to cleave fos RNA cl...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45179/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7972021/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.23.11123 |
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