Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

The multidrug resistance-associated protein (MRP) is a 180- to 195-kDa glycoprotein associated with multidrug resistance of human tumor cells. MRP is mainly located in the plasma membrane and it confers resistance by exporting natural product drugs out of the cell. Here we demonstrate that overexpre...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Müller, M, Meijer, C, Zaman, G J, Borst, P, Scheper, R J, Mulder, N H, de Vries, E G, Jansen, P L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45575/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7809167/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.26.13033
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