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Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

The multidrug resistance-associated protein (MRP) is a 180- to 195-kDa glycoprotein associated with multidrug resistance of human tumor cells. MRP is mainly located in the plasma membrane and it confers resistance by exporting natural product drugs out of the cell. Here we demonstrate that overexpre...

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Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Müller, M, Meijer, C, Zaman, G J, Borst, P, Scheper, R J, Mulder, N H, de Vries, E G, Jansen, P L
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1994
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45575/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7809167/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.26.13033
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