Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

The multidrug resistance-associated protein (MRP) is a 180- to 195-kDa glycoprotein associated with multidrug resistance of human tumor cells. MRP is mainly located in the plasma membrane and it confers resistance by exporting natural product drugs out of the cell. Here we demonstrate that overexpre...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Müller, M, Meijer, C, Zaman, G J, Borst, P, Scheper, R J, Mulder, N H, de Vries, E G, Jansen, P L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45575/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7809167/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.26.13033
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