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Mutation and catastrophe in the aging genome

In the 1960s, Leslie Orgel proposed what is now known as the error catastrophe theory of aging, arguing that errors in protein translation that reduce the fidelity of the protein-translating enzymes would lead to a feedback loop of increasingly inaccurate protein synthesis, terminating in the death...

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Detalles Bibliográficos
Publicado en:Exp Gerontol
Main Authors: Milholland, Brandon, Suh, Yousin, Vijg, Jan
Formato: Artigo
Idioma:Inglês
Publicado: 2017
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5480213/
https://ncbi.nlm.nih.gov/pubmed/28263867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2017.02.073
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