Nitric Oxide Inhibits the Degradation of IRP2

Iron-regulatory protein 2 (IRP2), a posttranscriptional regulator of iron metabolism, undergoes proteasomal degradation in iron-replete cells, while it is stabilized in iron deficiency or hypoxia. IRP2 also responds to nitric oxide (NO), as shown in various cell types exposed to pharmacological NO d...

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Bibliographic Details
Main Authors: Wang, Jian, Chen, Guohua, Pantopoulos, Kostas
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC548015/
https://ncbi.nlm.nih.gov/pubmed/15684386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.4.1347-1353.2005
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