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Conditional Derepression of Ferritin Synthesis in Cells Expressing a Constitutive IRP1 Mutant

Iron regulatory protein 1 (IRP1), a major posttranscriptional regulator of cellular iron and energy metabolism, is controlled by an iron-sulfur cluster switch. Cysteine-437 is critical for coordinating the cluster, and its replacement yields mutants that do not respond to iron perturbations and cons...

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Main Authors: Wang, Jian, Pantopoulos, Kostas
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2002
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC133884/
https://ncbi.nlm.nih.gov/pubmed/12052872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.13.4638-4651.2002
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