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Conditional Derepression of Ferritin Synthesis in Cells Expressing a Constitutive IRP1 Mutant
Iron regulatory protein 1 (IRP1), a major posttranscriptional regulator of cellular iron and energy metabolism, is controlled by an iron-sulfur cluster switch. Cysteine-437 is critical for coordinating the cluster, and its replacement yields mutants that do not respond to iron perturbations and cons...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC133884/ https://ncbi.nlm.nih.gov/pubmed/12052872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.13.4638-4651.2002 |
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