Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice

Amyloid-β (Aβ) deposition is one of the hallmarks of the amyloid hypothesis in Alzheimer’s disease (AD). Mouse models using APP-transgene overexpression to generate amyloid plaques have shown to model only certain parts of the disease. The extent to which the data from mice can be transferred to man...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol Commun
Main Authors: Steffen, Johannes, Krohn, Markus, Schwitlick, Christina, Brüning, Thomas, Paarmann, Kristin, Pietrzik, Claus U., Biverstål, Henrik, Jansone, Baiba, Langer, Oliver, Pahnke, Jens
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5480119/
https://ncbi.nlm.nih.gov/pubmed/28637503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0448-2
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