Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

As impaired insulin signalling (IIS) is a risk factor for Alzheimer’s disease we crossed mice (Tg2576) over-expressing human amyloid precursor protein (APP), with insulin receptor substrate 2 null (Irs2(−/−)) mice which develop insulin resistance. The resulting Tg2576/Irs2(−/−) animals had increased...

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Библиографические подробности
Главные авторы: Killick, Richard, Scales, Georgie, Leroy, Karelle, Causevic, Mirsada, Hooper, Claudie, Irvine, Elaine E., Choudhury, Agharul I, Drinkwater, Laura, Kerr, Fiona, Al-Qassab, Hind, Stephenson, John, Yilmaz, Zehra, Giese, K. Peter, Brion, Jean-Pierre, Withers, Dominic J., Lovestone, Simon
Формат: Artigo
Язык:Inglês
Опубликовано: Academic Press 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726921/
https://ncbi.nlm.nih.gov/pubmed/19523444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.06.032
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