Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice

Amyloid-β (Aβ) deposition is one of the hallmarks of the amyloid hypothesis in Alzheimer’s disease (AD). Mouse models using APP-transgene overexpression to generate amyloid plaques have shown to model only certain parts of the disease. The extent to which the data from mice can be transferred to man...

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Detalles Bibliográficos
Publicado en:Acta Neuropathol Commun
Autores principales: Steffen, Johannes, Krohn, Markus, Schwitlick, Christina, Brüning, Thomas, Paarmann, Kristin, Pietrzik, Claus U., Biverstål, Henrik, Jansone, Baiba, Langer, Oliver, Pahnke, Jens
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5480119/
https://ncbi.nlm.nih.gov/pubmed/28637503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0448-2
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