WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death

The WNT pathway mediates intercellular signaling that regulates cell fate in both normal development and cancer. It is widely appreciated that the WNT pathway is frequently dysregulated in human cancers through a variety of genetic and epigenetic mechanisms. Targets in the WNT pathway are being exte...

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Udgivet i:Sci Adv
Main Authors: Fischer, Marcus M., Cancilla, Belinda, Yeung, V. Pete, Cattaruzza, Fiore, Chartier, Cecile, Murriel, Christopher L., Cain, Jennifer, Tam, Raymond, Cheng, Chieh-Yang, Evans, James W., O’Young, Gilbert, Song, Xiaomei, Lewicki, John, Kapoun, Ann M., Gurney, Austin, Yen, Wan-Ching, Hoey, Timothy
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479655/
https://ncbi.nlm.nih.gov/pubmed/28691093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1700090
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