Intratumoral heterogeneity generated by Notch signaling promotes small cell lung cancer

The Notch signaling pathway mediates cell fate decisions(1,2) and is tumor suppressive or oncogenic depending on the context(2,3). During lung development, Notch pathway activation inhibits the differentiation of precursor cells to a neuroendocrine (NE) fate(4–6). In small cell lung cancer (SCLC), a...

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Publicado no:Nature
Main Authors: Lim, Jing Shan, Ibaseta, Alvaro, Fischer, Marcus M., Cancilla, Belinda, O’Young, Gilbert, Cristea, Sandra, Luca, Vincent C., Yang, Dian, Jahchan, Nadine S., Hamard, Cécile, Antoine, Martine, Wislez, Marie, Kong, Christina, Cain, Jennifer, Liu, Yu-Wang, Kapoun, Ann M., Garcia, K. Christopher, Hoey, Timothy, Murriel, Christopher L., Sage, Julien
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776014/
https://ncbi.nlm.nih.gov/pubmed/28489825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22323
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