RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations

Activating mutations in the Wnt pathway are a characteristic feature of colorectal cancer (CRC). The R-spondin (RSPO) family is a group of secreted proteins that enhance Wnt signaling and RSPO2 and RSPO3 gene fusions have been reported in CRC. We have previously shown that Wnt pathway blockers exhib...

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Pubblicato in:Sci Rep
Autori principali: Fischer, Marcus M., Yeung, V. Pete, Cattaruzza, Fiore, Hussein, Rajaa, Yen, Wan-Ching, Murriel, Christopher, Evans, James W., O’Young, Gilbert, Brunner, Alayne L., Wang, Min, Cain, Jennifer, Cancilla, Belinda, Kapoun, Ann, Hoey, Timothy
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5681666/
https://ncbi.nlm.nih.gov/pubmed/29127379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15704-y
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