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Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification

The Wnt pathway activates target genes by controlling the β-catenin-T-cell factor (TCF) transcriptional complex during embryonic development and cancer. This pathway can be potentiated by R-spondins, a family of proteins that bind RNF43/ZNRF3 E3 ubiquitin ligases and LGR4/5 receptors to prevent Friz...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Reis, Alice H., Sokol, Sergei Y.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8239024/
https://ncbi.nlm.nih.gov/pubmed/34183732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-92824-6
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