Intratumoral heterogeneity generated by Notch signaling promotes small cell lung cancer

The Notch signaling pathway mediates cell fate decisions(1,2) and is tumor suppressive or oncogenic depending on the context(2,3). During lung development, Notch pathway activation inhibits the differentiation of precursor cells to a neuroendocrine (NE) fate(4–6). In small cell lung cancer (SCLC), a...

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Publicat a:Nature
Autors principals: Lim, Jing Shan, Ibaseta, Alvaro, Fischer, Marcus M., Cancilla, Belinda, O’Young, Gilbert, Cristea, Sandra, Luca, Vincent C., Yang, Dian, Jahchan, Nadine S., Hamard, Cécile, Antoine, Martine, Wislez, Marie, Kong, Christina, Cain, Jennifer, Liu, Yu-Wang, Kapoun, Ann M., Garcia, K. Christopher, Hoey, Timothy, Murriel, Christopher L., Sage, Julien
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776014/
https://ncbi.nlm.nih.gov/pubmed/28489825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22323
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