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Cyclin G1 regulates the outcome of taxane-induced mitotic checkpoint arrest
Anti-mitotic chemotherapeutic agents such as taxanes activate the spindle assembly checkpoint (SAC) to arrest anaphase onset, but taxane-exposed cells eventually undergo slippage to exit mitosis. The therapeutic efficacy of taxanes depends on whether slippage after SAC arrest culminates in continued...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3351588/ https://ncbi.nlm.nih.gov/pubmed/22056875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.431 |
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