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A Telomere Dependent DNA Damage Checkpoint Induced by Prolonged Mitotic Arrest
Telomere shortening and disruption of telomeric components are pathways that induce telomere deprotection. Here we describe another pathway, where prolonged mitotic arrest induces damage signals at telomeres in human cells. Exposure to microtubule drugs, kinesin inhibitors, proteasome inhibitors or...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3319806/ https://ncbi.nlm.nih.gov/pubmed/22407014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2245 |
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