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Persistent telomere damage induces by-pass of mitosis and tetraploidy
Tetraploidization has been proposed as an intermediate step toward aneuploidy in human cancer but a general mechanism for the induction of tetraploidy during tumorigenesis is lacking. We report that tetraploidization occurs in p53-deficient cells experiencing a prolonged DNA damage signal due to per...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2854042/ https://ncbi.nlm.nih.gov/pubmed/20371347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.01.031 |
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