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Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication
We report that mouse liver cells are highly resistant to extensive telomere dysfunction. In proliferating cells, telomere dysfunction results in chromosome end fusions, a DNA damage signal, and apoptosis or senescence. To determine the consequences of telomere dysfunction in noncycling cells, we use...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2006
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1578691/ https://ncbi.nlm.nih.gov/pubmed/17015429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1453606 |
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