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Stop pulling my strings — what telomeres taught us about the DNA damage response

Mammalian cells have evolved specialized mechanisms to sense and repair double-strand breaks (DSBs) to maintain genomic stability. However, in certain cases, the activity of these pathways can lead to aberrant DNA repair, genomic instability and tumorigenesis. One such case is DNA repair at the natu...

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Detalhes bibliográficos
Publicado no:Nat Rev Mol Cell Biol
Main Authors: Lazzerini-Denchi, Eros, Sfeir, Agnel
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385261/
https://ncbi.nlm.nih.gov/pubmed/27165790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrm.2016.43
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