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Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore
Mutations in the telomere-binding protein POT1 are associated with solid tumors and leukemias. POT1 alterations cause rapid telomere elongation, ATR kinase activation, telomere fragility, and accelerated tumor development. Here, we define the impact of mutant POT1 alleles through complementary genet...
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| 出版年: | Genes Dev |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7706707/ https://ncbi.nlm.nih.gov/pubmed/33122293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.337287.120 |
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