Carregant...

Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore

Mutations in the telomere-binding protein POT1 are associated with solid tumors and leukemias. POT1 alterations cause rapid telomere elongation, ATR kinase activation, telomere fragility, and accelerated tumor development. Here, we define the impact of mutant POT1 alleles through complementary genet...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Genes Dev
Autors principals: Pinzaru, Alexandra M., Kareh, Mike, Lamm, Noa, Lazzerini-Denchi, Eros, Cesare, Anthony J., Sfeir, Agnel
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7706707/
https://ncbi.nlm.nih.gov/pubmed/33122293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.337287.120
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!