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Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore
Mutations in the telomere-binding protein POT1 are associated with solid tumors and leukemias. POT1 alterations cause rapid telomere elongation, ATR kinase activation, telomere fragility, and accelerated tumor development. Here, we define the impact of mutant POT1 alleles through complementary genet...
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| Publicat a: | Genes Dev |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7706707/ https://ncbi.nlm.nih.gov/pubmed/33122293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.337287.120 |
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