Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore

Mutations in the telomere-binding protein POT1 are associated with solid tumors and leukemias. POT1 alterations cause rapid telomere elongation, ATR kinase activation, telomere fragility, and accelerated tumor development. Here, we define the impact of mutant POT1 alleles through complementary genet...

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Bibliografiske detaljer
Udgivet i:Genes Dev
Main Authors: Pinzaru, Alexandra M., Kareh, Mike, Lamm, Noa, Lazzerini-Denchi, Eros, Cesare, Anthony J., Sfeir, Agnel
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7706707/
https://ncbi.nlm.nih.gov/pubmed/33122293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.337287.120
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