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Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis
Genome sequencing studies have revealed a number of cancer-associated mutations in the telomerebinding factor POT1. Here, we show that when combined with p53 deficiency, depletion of murine POT1a in common lymphoid progenitor cells fosters genetic instability, accelerates the onset, and increases th...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6145145/ https://ncbi.nlm.nih.gov/pubmed/27239034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.008 |
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