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Mammalian Polymerase Theta Promotes Alternative-NHEJ and Suppresses Recombination

The alternative nonhomologous end-joining (alt-NHEJ) machinery facilitates a number of genomic rearrangements, some of which can lead to cellular transformation. This error-prone repair pathway is triggered upon telomere de-protection to promote the formation of deleterious chromosome end-to-end fus...

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Detalles Bibliográficos
Publicado en:Nature
Main Authors: Mateos-Gomez, Pedro A., Gong, Fade, Nair, Nidhi, Miller, Kyle M., Lazzerini-Denchi, Eros, Sfeir, Agnel
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718306/
https://ncbi.nlm.nih.gov/pubmed/25642960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14157
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