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Mammalian Polymerase Theta Promotes Alternative-NHEJ and Suppresses Recombination
The alternative nonhomologous end-joining (alt-NHEJ) machinery facilitates a number of genomic rearrangements, some of which can lead to cellular transformation. This error-prone repair pathway is triggered upon telomere de-protection to promote the formation of deleterious chromosome end-to-end fus...
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| Pubblicato in: | Nature |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4718306/ https://ncbi.nlm.nih.gov/pubmed/25642960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14157 |
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