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Prolonged mitotic arrest induces a caspase-dependent DNA damage response at telomeres that determines cell survival
A delay in the completion of metaphase induces a stress response that inhibits further cell proliferation or induces apoptosis. This response is thought to protect against genomic instability and is important for the effects of anti-mitotic cancer drugs. Here, we show that mitotic arrest induces a c...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Sci Rep |
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| Κύριοι συγγραφείς: | , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Nature Publishing Group
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4882748/ https://ncbi.nlm.nih.gov/pubmed/27230693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26766 |
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