Proteasome inhibition enhances the efficacy of volasertib-induced mitotic arrest in AML in vitro and prolongs survival in vivo

Elderly and frail patients, diagnosed with acute myeloid leukemia (AML) and ineligible to undergo intensive treatment, have a dismal prognosis. The small molecule inhibitor volasertib induces a mitotic block via inhibition of polo-like kinase 1 and has shown remarkable anti-leukemic activity when co...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Schnerch, Dominik, Schüler, Julia, Follo, Marie, Felthaus, Julia, Wider, Dagmar, Klingner, Kathrin, Greil, Christine, Duyster, Justus, Engelhardt, Monika, Wäsch, Ralph
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400573/
https://ncbi.nlm.nih.gov/pubmed/28416751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15503
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