Suppression of APC/C(Cdh1) has subtype specific biological effects in acute myeloid leukemia

The E3 ubiquitin ligase and tumor suppressor APC/C(Cdh1) is crucial for cell cycle progression, development and differentiation in many cell types. However, little is known about the role of Cdh1 in hematopoiesis. Here we analyzed Cdh1 expression and function in malignant hematopoiesis. We found a s...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ewerth, Daniel, Schmidts, Andrea, Hein, Manuel, Schnerch, Dominik, Kvainickas, Arunas, Greil, Christine, Duyster, Justus, Engelhardt, Monika, Wäsch, Ralph
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217013/
https://ncbi.nlm.nih.gov/pubmed/27374082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10196
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