Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase

Kynurenine-3-monooxygenase (KMO) is a key FAD-dependent enzyme of tryptophan metabolism. In animal models, KMO inhibition has shown benefit in neurodegenerative diseases such as Huntington's and Alzheimer's. Most recently it has been identified as a target for acute pancreatitis multiple o...

詳細記述

保存先:
書誌詳細
出版年:Nat Commun
主要な著者: Hutchinson, Jonathan P., Rowland, Paul, Taylor, Mark R. D., Christodoulou, Erica M., Haslam, Carl, Hobbs, Clare I., Holmes, Duncan S., Homes, Paul, Liddle, John, Mole, Damian J., Uings, Iain, Walker, Ann L., Webster, Scott P., Mowat, Christopher G., Chung, Chun-wa
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477544/
https://ncbi.nlm.nih.gov/pubmed/28604669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15827
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