Kynurenine 3-monooxygenase is a critical regulator of renal ischemia–reperfusion injury

Acute kidney injury (AKI) following ischemia–reperfusion injury (IRI) has a high mortality and lacks specific therapies. Here, we report that mice lacking kynurenine 3-monooxygenase (KMO) activity (Kmo(null) mice) are protected against AKI after renal IRI. We show that KMO is highly expressed in the...

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Publicado en:Exp Mol Med
Autores principales: Zheng, Xiaozhong, Zhang, Ailiang, Binnie, Margaret, McGuire, Kris, Webster, Scott P., Hughes, Jeremy, Howie, Sarah E. M., Mole, Damian J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6374422/
https://ncbi.nlm.nih.gov/pubmed/30760699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-019-0210-x
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