Diclofenac Identified as a Kynurenine 3-Monooxygenase Binder and Inhibitor by Molecular Similarity Techniques

[Image: see text] In this study, we apply a battery of molecular similarity techniques to known inhibitors of kynurenine 3-monooxygenase (KMO), querying each against a repository of approved, experimental, nutraceutical, and illicit drugs. Four compounds are assayed against KMO. Subsequently, diclof...

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Опубликовано в: :ACS Omega
Главные авторы: Shave, Steven, McGuire, Kris, Pham, Nhan T., Mole, Damian J., Webster, Scott P., Auer, Manfred
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2018
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044753/
https://ncbi.nlm.nih.gov/pubmed/30023839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b02091
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