Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase

Kynurenine-3-monooxygenase (KMO) is a key FAD-dependent enzyme of tryptophan metabolism. In animal models, KMO inhibition has shown benefit in neurodegenerative diseases such as Huntington's and Alzheimer's. Most recently it has been identified as a target for acute pancreatitis multiple o...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Hutchinson, Jonathan P., Rowland, Paul, Taylor, Mark R. D., Christodoulou, Erica M., Haslam, Carl, Hobbs, Clare I., Holmes, Duncan S., Homes, Paul, Liddle, John, Mole, Damian J., Uings, Iain, Walker, Ann L., Webster, Scott P., Mowat, Christopher G., Chung, Chun-wa
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477544/
https://ncbi.nlm.nih.gov/pubmed/28604669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15827
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