β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections

Chronic pulmonary colonization with bacterial pathogens, particularly Pseudomonas aeruginosa, is the primary cause of morbidity and mortality in patients with cystic fibrosis (CF). We observed that β1-integrins accumulate on the luminal membrane of upper-airway epithelial cells from mice and humans...

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Publicat a:Cell Host Microbe
Autors principals: Grassmé, Heike, Henry, Brian, Ziobro, Regan, Becker, Katrin Anne, Riethmüller, Joachim, Gardner, Aaron, Seitz, Aaron P., Steinmann, Joerg, Lang, Stephan, Ward, Christopher, Schuchman, Edward H., Caldwell, Charles C., Kamler, Markus, Edwards, Michael J., Brodlie, Malcolm, Gulbins, Erich
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475347/
https://ncbi.nlm.nih.gov/pubmed/28552668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2017.05.001
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