β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections

Chronic pulmonary colonization with bacterial pathogens, particularly Pseudomonas aeruginosa, is the primary cause of morbidity and mortality in patients with cystic fibrosis (CF). We observed that β1-integrins accumulate on the luminal membrane of upper-airway epithelial cells from mice and humans...

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Bibliographic Details
Published in:Cell Host Microbe
Main Authors: Grassmé, Heike, Henry, Brian, Ziobro, Regan, Becker, Katrin Anne, Riethmüller, Joachim, Gardner, Aaron, Seitz, Aaron P., Steinmann, Joerg, Lang, Stephan, Ward, Christopher, Schuchman, Edward H., Caldwell, Charles C., Kamler, Markus, Edwards, Michael J., Brodlie, Malcolm, Gulbins, Erich
Format: Artigo
Language:Inglês
Published: Cell Press 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475347/
https://ncbi.nlm.nih.gov/pubmed/28552668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2017.05.001
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