β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections

Chronic pulmonary colonization with bacterial pathogens, particularly Pseudomonas aeruginosa, is the primary cause of morbidity and mortality in patients with cystic fibrosis (CF). We observed that β1-integrins accumulate on the luminal membrane of upper-airway epithelial cells from mice and humans...

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Bibliografiska uppgifter
I publikationen:Cell Host Microbe
Huvudupphovsmän: Grassmé, Heike, Henry, Brian, Ziobro, Regan, Becker, Katrin Anne, Riethmüller, Joachim, Gardner, Aaron, Seitz, Aaron P., Steinmann, Joerg, Lang, Stephan, Ward, Christopher, Schuchman, Edward H., Caldwell, Charles C., Kamler, Markus, Edwards, Michael J., Brodlie, Malcolm, Gulbins, Erich
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cell Press 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475347/
https://ncbi.nlm.nih.gov/pubmed/28552668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2017.05.001
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