Differential contribution of the three Aph1 genes to γ-secretase activity in vivo

γ-Secretase is the protease responsible for amyloid β peptide release and is needed for Notch, N-Cadherin, and possibly other signaling pathways. The protease complex consists of at least four subunits, i.e., Presenilin, Aph1, Pen2, and Nicastrin. Two different genes encode Aph1A and Aph1B in man. A...

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Autori principali: Serneels, Lutgarde, Dejaegere, Tim, Craessaerts, Katleen, Horré, Katrien, Jorissen, Ellen, Tousseyn, Thomas, Hébert, Sébastien, Coolen, Marcel, Martens, Gerard, Zwijsen, An, Annaert, Wim, Hartmann, Dieter, De Strooper, Bart
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC547495/
https://ncbi.nlm.nih.gov/pubmed/15665098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408901102
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