Differential contribution of the three Aph1 genes to γ-secretase activity in vivo

γ-Secretase is the protease responsible for amyloid β peptide release and is needed for Notch, N-Cadherin, and possibly other signaling pathways. The protease complex consists of at least four subunits, i.e., Presenilin, Aph1, Pen2, and Nicastrin. Two different genes encode Aph1A and Aph1B in man. A...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Serneels, Lutgarde, Dejaegere, Tim, Craessaerts, Katleen, Horré, Katrien, Jorissen, Ellen, Tousseyn, Thomas, Hébert, Sébastien, Coolen, Marcel, Martens, Gerard, Zwijsen, An, Annaert, Wim, Hartmann, Dieter, De Strooper, Bart
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2005
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC547495/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15665098/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408901102
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky