Peripherally Selective Cannabinoid 1 Receptor (CB1R) Agonists for the Treatment of Neuropathic Pain

Alleviation of neuropathic pain by cannabinoids is limited by their central nervous system (CNS) side effects. Indole and indene compounds were engineered for high hCB1R affinity, peripheral selectivity, metabolic stability, and in vivo efficacy. An epithelial cell line assay identified candidates w...

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Bibliografiske detaljer
Udgivet i:J Med Chem
Main Authors: Seltzman, Herbert H., Shiner, Craig, Hirt, Erin E., Gilliam, Anne F., Thomas, Brian F., Maitra, Rangan, Snyder, Rod, Black, Sherry L., Patel, Purvi R., Mulpuri, Yatendra, Spigelman, Igor
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474949/
https://ncbi.nlm.nih.gov/pubmed/27482723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00516
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