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Enzyme-Catalyzed Intramolecular Enantioselective Hydroalkoxylation

Hydroalkoxylation is a powerful and efficient method of forming C–O bonds and cyclic ethers in synthetic chemistry. In studying the biosynthesis of the fungal natural product herqueinone, we identified an enzyme that can perform an intramolecular enantio-selective hydroalkoxylation reaction. PhnH ca...

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Détails bibliographiques
Publié dans:J Am Chem Soc
Auteurs principaux: Gao, Shu-Shan, Garcia-Borràs, Marc, Barber, Joyann S., Hai, Yang, Duan, Abing, Garg, Neil K., Houk, K. N., Tang, Yi
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474393/
https://ncbi.nlm.nih.gov/pubmed/28240554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b01089
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