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Phenalenone Polyketide Cyclization Catalyzed by Fungal Polyketide Synthase and Flavin-Dependent Monooxygenase

Phenalenones are polyketide natural products that display diverse structures and biological activities. The core of phenalenones is a peri-fused tricyclic ring system cyclized from a linear polyketide precursor via unresolved mechanism. Towards understanding the unusual cyclization steps, the phn bi...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Gao, Shu-Shan, Duan, Abing, Xu, Wei, Yu, Peiyuan, Hang, Leibniz, Houk, K. N., Tang, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988900/
https://ncbi.nlm.nih.gov/pubmed/26978228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b01528
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