Structure-Activity Relationships of Different β-Lactam Antibiotics against a Soluble Form of Enterococcus faecium PBP5, a Type II Bacterial Transpeptidase

Penicillin-binding proteins (PBPs) catalyze the essential reactions in the biosynthesis of cell wall peptidoglycan from glycopeptide precursors. β-Lactam antibiotics normally interfere with this process by reacting covalently with the active site serine to form a stable acyl-enzyme. The design of no...

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Autors principals: Hujer, Andrea M., Kania, Malgosia, Gerken, Thomas, Anderson, Vernon E., Buynak, John D., Ge, Xiaoxia, Caspers, Patrick, Page, Malcolm G. P., Rice, Louis B., Bonomo, Robert A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC547200/
https://ncbi.nlm.nih.gov/pubmed/15673741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.2.612-618.2005
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