Discovery and characterization of small molecule Rac1 inhibitors

Aberrant activation of Rho GTPase Rac1 has been observed in various tumor types, including pancreatic cancer. Rac1 activates multiple signaling pathways that lead to uncontrolled proliferation, invasion and metastasis. Thus, inhibition of Rac1 activity is a viable therapeutic strategy for proliferat...

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Publicat a:Oncotarget
Autors principals: Arnst, Jamie L., Hein, Ashley L., Taylor, Margaret A., Palermo, Nick Y., Contreras, Jacob I., Sonawane, Yogesh A., Wahl, Andrew O., Ouellette, Michel M., Natarajan, Amarnath, Yan, Ying
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470993/
https://ncbi.nlm.nih.gov/pubmed/28410221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16656
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