Discovery and characterization of small molecule Rac1 inhibitors

Aberrant activation of Rho GTPase Rac1 has been observed in various tumor types, including pancreatic cancer. Rac1 activates multiple signaling pathways that lead to uncontrolled proliferation, invasion and metastasis. Thus, inhibition of Rac1 activity is a viable therapeutic strategy for proliferat...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Arnst, Jamie L., Hein, Ashley L., Taylor, Margaret A., Palermo, Nick Y., Contreras, Jacob I., Sonawane, Yogesh A., Wahl, Andrew O., Ouellette, Michel M., Natarajan, Amarnath, Yan, Ying
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470993/
https://ncbi.nlm.nih.gov/pubmed/28410221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16656
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