Discovery and characterization of small molecule Rac1 inhibitors

Aberrant activation of Rho GTPase Rac1 has been observed in various tumor types, including pancreatic cancer. Rac1 activates multiple signaling pathways that lead to uncontrolled proliferation, invasion and metastasis. Thus, inhibition of Rac1 activity is a viable therapeutic strategy for proliferat...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Arnst, Jamie L., Hein, Ashley L., Taylor, Margaret A., Palermo, Nick Y., Contreras, Jacob I., Sonawane, Yogesh A., Wahl, Andrew O., Ouellette, Michel M., Natarajan, Amarnath, Yan, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470993/
https://ncbi.nlm.nih.gov/pubmed/28410221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16656
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