Discovery and characterization of small molecule Rac1 inhibitors

Aberrant activation of Rho GTPase Rac1 has been observed in various tumor types, including pancreatic cancer. Rac1 activates multiple signaling pathways that lead to uncontrolled proliferation, invasion and metastasis. Thus, inhibition of Rac1 activity is a viable therapeutic strategy for proliferat...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Oncotarget
Päätekijät: Arnst, Jamie L., Hein, Ashley L., Taylor, Margaret A., Palermo, Nick Y., Contreras, Jacob I., Sonawane, Yogesh A., Wahl, Andrew O., Ouellette, Michel M., Natarajan, Amarnath, Yan, Ying
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Impact Journals LLC 2017
Aiheet:
Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470993/
https://ncbi.nlm.nih.gov/pubmed/28410221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16656
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