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Characterization of DNA substrate binding to the phosphatase domain of the DNA repair enzyme, PNKP

Polynucleotide kinase/phosphatase (PNKP) is a DNA strand break repair enzyme that uses separate 5′ kinase and 3′ phosphatase active sites to convert damaged 5′-hydroxyl/3′-phosphate strand termini to ligatable 5′-phosphate/3′-hydroxyl ends. The phosphatase active site has received particular attenti...

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Publicat a:Biochemistry
Autors principals: Havali-Shahriari, Zahra, Weinfeld, Michael, Mark Glover, J. N.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469602/
https://ncbi.nlm.nih.gov/pubmed/28276686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01236
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