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Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates

Polynucleotide kinase/phosphatase (PNKP) is a critical mammalian DNA repair enzyme that generates 5′-phosphate and 3′-hydroxyl groups at damaged DNA termini that are required for subsequent processing by DNA ligases and polymerases. The PNKP phosphatase domain recognizes 3′-phosphate termini within...

詳細記述

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書誌詳細
主要な著者: Coquelle, Nicolas, Havali-Shahriari, Zahra, Bernstein, Nina, Green, Ruth, Glover, J. N. Mark
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248541/
https://ncbi.nlm.nih.gov/pubmed/22171004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112036108
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