The structural basis for substrate recognition by mammalian polynucleotide kinase 3’ phosphatase

Mammalian polynucleotide kinase 3’ phosphatase (PNK) plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base-excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extensi...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Garces, Fernando, Pearl, Laurence H., Oliver, Antony W.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820033/
https://ncbi.nlm.nih.gov/pubmed/22055185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.08.036
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